Chen Wenjie · 陈文杰

AI for Biology生物人工智能 Computational Biology计算生物学 Protein Design蛋白质设计

I study how computational models represent, understand and design biological systems.我研究计算模型如何表征生物系统,如何理解它,又能否用它做设计。

Using machine learning to understand, predict and design biomolecules.用机器学习理解、预测和设计生物分子。

Currently exploring当前关注

  • Protein representations蛋白质表征
  • Structured-null evaluation结构化零假设评估
  • Computational protein design计算蛋白质设计
  • Cross-family generalization跨家族泛化

Research operating system研究方法系统

From a question to a defensible claim从问题走向经得起检验的论断

The common thread across my projects is not a particular model. It is an evaluation loop designed to make biological AI results harder to fool.贯穿这些项目的不是某一种模型,而是一套评估闭环,用来让生物 AI 结果更难自欺。

  1. 01

    Ask a falsifiable question提出可证伪的问题

    Define what the model should know — and what evidence would prove that it does not.先说清模型应该知道什么,也说清什么证据能证明它不知道。

  2. 02

    Design for deployment按真实部署设计评估

    Use family-held-out splits or external cohorts instead of convenient random partitions.用家族留出划分或外部队列,而不是图省事的随机划分。

  3. 03

    Stress-test the signal对信号做压力测试

    Challenge apparent success with structured nulls, calibration checks and leakage audits.表面的成功要经得起结构化零假设、校准检查和泄漏审计。

  4. 04

    Bound the claim给论断划出边界

    Report what survives the controls, preserve limitations, and make failure reproducible.只报告经得住对照的结论,局限照写,失败也要能复现。

Selected Research精选研究

Selected research projects精选研究项目

Research Atlas研究图谱

A living map of what I study一张还在生长的研究地图

Explore the tree, or switch to the list for a quick, fully accessible overview — every node links to the work behind it.可以在树状图里点着看,也可以切到列表快速浏览。每个节点都连着它背后的工作。

Branches分支
4
Active threads活跃线索
12
Projects项目
3
Published已发表
3
Submitted已投稿
2
Publications论文成果

Recent publications近期论文成果

  1. 2026

    Highly SERS active composite of silver nanospheres-decorated Ag nanostar/ZIF-8 for determination of diquat and thiram residuesHighly SERS active composite of silver nanospheres-decorated Ag nanostar/ZIF-8 for determination of diquat and thiram residues

    Wei Zhang, Kuang Luo, Wenjie Chen, Min Chen, Ning Cai, Jumei LiWei Zhang,Kuang Luo,Wenjie Chen,Min Chen,Ning Cai,Jumei Li

    Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy · Co-author (third author).Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy · 共同作者(第三作者)。

  2. 2025

    Exclusive core-satellite composite based on sandwich Ag-MOF-Ag nanoshell with abundant hotspots for sensitive monitoring of antibiotic and pesticide residues in milkExclusive core-satellite composite based on sandwich Ag-MOF-Ag nanoshell with abundant hotspots for sensitive monitoring of antibiotic and pesticide residues in milk

    Yiting Liu, Wenjie Chen, Jie Yang, Ning Cai, Jumei LiYiting Liu,Wenjie Chen,Jie Yang,Ning Cai,Jumei Li

    Colloids and Surfaces A: Physicochemical and Engineering Aspects · Co-author (second author).Colloids and Surfaces A: Physicochemical and Engineering Aspects · 共同作者(第二作者)。

  3. 2025

    Metal–organic framework-based SERS substrates with enrichment and sieving capability for trace detection of small-molecule biomarkers in serumMetal–organic framework-based SERS substrates with enrichment and sieving capability for trace detection of small-molecule biomarkers in serum

    Yiwen Gui, Kuang Luo, Wenjie Chen, Ning Cai, Lijun You, Jumei LiYiwen Gui,Kuang Luo,Wenjie Chen,Ning Cai,Lijun You,Jumei Li

    Microchemical Journal · Co-author (third author).Microchemical Journal · 共同作者(第三作者)。

Writing写作

Latest writing最新文章

About关于

Research-first, evaluation-obsessed研究优先,评估较真

I am a researcher working across AI for biology — protein language models, computational protein design, and trustworthy biomedical AI. My current focus is representation analysis under strict evaluation: structured nulls, family-held-out splits, and explicit claim boundaries.我做生物 AI 方向的研究,覆盖蛋白质语言模型、计算蛋白质设计和可信生物医学 AI。目前的重点是表征分析,评估必须足够严格:结构化零假设、家族留出划分,以及明确的论断边界。

I work with Python, PyTorch and reproducible Linux-based pipelines, and I write about evaluation design and interpretability in my research notes.工作环境是 Python、PyTorch 和可复现的 Linux 流程。评估设计和可解释性方面的思考,写在研究笔记里。

Focus方向
AI for Biology · Protein Design生物人工智能 · 蛋白质设计
Tools工具
Python · PyTorch · Linux · LaTeX
Training训练
问序生研科研训练计划
Contact联系
Email